Magnetic Field Effects
Magnetic particles bound to cell membranes - 0 pulse (left), 50 pulses
Field-induced molecular changes must take place if electric and magnetic
fields cause biological effects. However, it is increasingly difficult
to understand how potentially causal molecular changes could be achieved
by weak 50-60 Hz exposures. For this reason, we have investigated theoretically
a biophysical mechanism by which transient magnetic fields could generate
molecular changes greater than those from competing influences such as
temperature variations, mechanical perturbations and endogenous biological
fields. This has led to the specific hypothesis that if biological magnetite
or contaminant magnetic particles were bound to cell membranes, then transient
magnetic fields with magnitudes between about 2x10e-3 T and the particle's
coercive force, and durations between about 10e-5 and 0.1 s satisfy an
approximate energetic constraint for creating metastable hydrophilic pores.
A new membrane pore with a lifetime of seconds could create a potentially
causal molecular change by admitting foreign molecules into the cytosol.
This could be relevant to rare environmental transients, and to the very
large pulses used in biomagnetic stimulation.
Bound Magnetic Particles and Pore Creation