WEAVER GROUP
Harvard-MIT Division of Health Sciences and Technology
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In Silico Bioelectromagnetics
Electroporation Theory
Microconduit Creation
Weak Field Effects
Microconduit Creation
Skin Electroporation

Magnetic Field Effects

      
Magnetic particles bound to cell membranes - 0 pulse (left), 50 pulses (right) 

Field-induced molecular changes must take place if electric and magnetic fields cause biological effects. However, it is increasingly difficult to understand how potentially causal molecular changes could be achieved by weak 50-60 Hz exposures. For this reason, we have investigated theoretically a biophysical mechanism by which transient magnetic fields could generate molecular changes greater than those from competing influences such as temperature variations, mechanical perturbations and endogenous biological fields. This has led to the specific hypothesis that if biological magnetite or contaminant magnetic particles were bound to cell membranes, then transient magnetic fields with magnitudes between about 2x10e-3 T and the particle's coercive force, and durations between about 10e-5 and 0.1 s satisfy an approximate energetic constraint for creating metastable hydrophilic pores. A new membrane pore with a lifetime of seconds could create a potentially causal molecular change by admitting foreign molecules into the cytosol. This could be relevant to rare environmental transients, and to the very large pulses used in biomagnetic stimulation.

 Membrane Bound Magnetic Particles and Pore Creation