WEAVER GROUP
Harvard-MIT Division of Health Sciences and Technology
Home People Research Publications Links Contact

In Silico Bioelectromagnetics
Electroporation Theory
Magnetic Field Effects
Weak Field Effects
Microconduit Creation
Skin Electroporation

In Silico Bioelectromagnetics


Issues of electrical, thermal, and chemical transport are essential in reaching an understanding of Biological processes. Our general approach to transport problems is based on discretizing tissue and cells and testing hypothetical models of local transport between neighboring nodes of the discretized lattice.

A didactic multicellular system model. (a) Endothelial layer with cells connected by tight junctions, bathed in saline (top), an invagination (left) and a gap (right) with underlying subendothelial cells (~15% extracellular fluid). (b) G_m(f) from 10 Hz to 10 GHz at cell membrane sites A-F. (c-h) equipotentials for 100 Hz, 100 kHz, 1 MHz, 10 MHz, 100 MHz and 1 GHz. (i-n) SAR distributions (spatially averaged value of 1 W/kg; color bar: black = 0 to white >= 2 W/kg) for the same frequencies. Field amplification through current or voltage concentration changes with frequency, exhibiting significant spatial heterogeneity until the microwave range is reached, where cellular structure becomes almost "electrically invisible."