In Silico Bioelectromagnetics
Issues of electrical, thermal, and chemical transport are essential
in reaching an understanding of Biological processes. Our general approach
to transport problems is based on discretizing tissue and cells and testing
hypothetical models of local transport between neighboring nodes of the
A didactic multicellular system model. (a)
Endothelial layer with cells connected by tight junctions, bathed
in saline (top), an invagination (left) and a gap (right)
with underlying subendothelial cells (~15% extracellular fluid).
(b) G_m(f) from 10 Hz to 10 GHz at cell membrane sites A-F.
(c-h) equipotentials for 100 Hz, 100 kHz, 1 MHz, 10 MHz, 100 MHz and 1 GHz.
(i-n) SAR distributions (spatially averaged value of
1 W/kg; color bar: black = 0 to white >= 2 W/kg) for the
same frequencies. Field amplification through current or voltage
concentration changes with frequency, exhibiting significant spatial
heterogeneity until the microwave range is reached, where cellular
structure becomes almost "electrically invisible."