Electroporation theory. Concepts and mechanisms.
Weaver JC Methods Mol Biol (BU3), 1995; 48 3-28
The basic features of electrical and mechanical behavior of
electroporated cell membranes are reasonably well
established experimentally. Overall, the electrical and
mechanical features of electroporation are consistent with a
transient aqueous pore hypothesis, and several features,
such as membrane rupture and reversible electrical
breakdown, are reasonably well described quantitatively.
This gives confidence that "electroporation" is an
attractive hypothesis, and that the appearance of temporary
pores owing to the simultaneous contributions of thermal
fluctuations ("kT energy") and an elevated
transmembrane voltage ("electric field energy") is
the microscopic basis of electroporation.