Sampling: a critical problem in biosensing.
Weaver JC Med Biol Eng Comput (LPN), 1990 May; 28 (3): B3-9
Biosensing is widely recognised to be of potentially major
importance to medicine and related fields, but in spite of a
large number of impressive and important advances,
widespread practical application has lagged. We examine the
thesis that 'sampling' is a process which involves all of
the phenomena which are associated with the transport of
analyte molecules to the active sensor site, and that
problems associated with this process are now the limiting
factor in further use of many existing biosensors. We
conclude that an integrated process of sampling and sensing
should be emphasised in developing new biosensing systems,
and propose several new approaches.